VIII. Academic Studies Congress | Andizhan, Uzbekistan

A Promising Therapeutic Target in Neurodegenerative Diseases: Sestrin-3

Not scheduled

20m

Description

Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis are the more common, multi-factorial, and progressive diseases in today’s world. The most common etiology of neurodegenerative disorders is aging, oxidative stress, and mitochondrial dysfunction. Modern medicines for the treatment of neurodegenerative diseases improve the patient’s quality of life, but no treatment slows down or prevents the development and progression of the disease. The greatest disadvantage of these drugs is that they cause serious side effects in their chronic use. New agents with low side effect profiles in the long term are needed for new therapeutic targets. Recent studies have shown that Sestrin-3, a stress-inducible metabolic protein, suppresses reactive oxygen species, regulates metabolism and inflammation, and provides cellular protection against various harmful stimuli including genotoxicity and oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, and hypoxia. With ground breaking research into the regulation and signaling mechanisms of sestrin-3, although our knowledge of its potential role and its importance to host response has increased considerably, its function in neurodegenerative diseases remains unclear. The present study compiled in detail the information in the literature to draw attention to sestrin-3, which has the potential to be a major therapeutic target in neurodegenerative diseases.
Keywords: Alzheimer’s Disease, Parkinson’s Disease,Neurodegenerative Diseases, Oxidative Stress